网站地图 联系我们 │ │ │ |
所况简介 机构设置 科研队伍 院地合作 党群园地 国际交流 博士后 研究生教育 信息公开
科研进展
成果报道
最新重要论文(影响因子PNAS及以上)
发表论文数据库
所级学术报告
科学成果
专题
所史丛书
所庆专辑
建所50周年画册
现在位置:  > 科研进展 > 最新重要论文(影响因子PNAS及以上)
A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation, Nat Cell Biol, 30 Sep 2019
2019-09-30 | 【     】【打印】【关闭

Nature Cell Biology30 September, 2019,DOI:

A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation

Kang Zhao, Sha Cheng, Na Miao, Ping Xu, Xiaohua Lu, Yuhan Zhang, Ming Wang, Xuan Ouyang, Xun Yuan, Weiwei Liu, Xin Lu, Peng Zhou, Jiaqi Gu, Yiqun Zhang, Ding Qiu, Zhaohui Jin, Chen Su, Chao Peng, Jian-Hua Wang, Meng-Qiu Dong, Youzhong Wan, Jinbiao Ma, Hong Cheng, Ying Huang & Yang Yu

Abstract

The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila, Panoramix enforces transcriptional silencing by binding to the target-engaged Piwi–piRNA complex, although the precise mechanisms by which this occurs remain elusive. Here, we show that Panoramix functions together with a germline-specific paralogue of a nuclear export factor, dNxf2, and its cofactor dNxt1 (p15), to suppress transposon expression. The transposon RNA-binding protein dNxf2 is required for animal fertility and Panoramix-mediated silencing. Transient tethering of dNxf2 to nascent transcripts leads to their nuclear retention. The NTF2 domain of dNxf2 competes dNxf1 (TAP) off nucleoporins, a process required for proper RNA export. Thus, dNxf2 functions in a Panoramix–dNxf2-dependent TAP/p15 silencing (Pandas) complex that counteracts the canonical RNA exporting machinery and restricts transposons to the nuclear peripheries. Our findings may have broader implications for understanding how RNA metabolism modulates heterochromatin formation.

文章链接:

相关报道:http://bjjufeng.com.cn/kyjz/zxdt/201909/t20190929_5402610.html

 

 

          
版权所有:韩国三级片     
地址:北京市朝阳区大屯路15号(100101) 电话:010-64889872
意见反馈联系人:侯文茹 电子邮件:houwenru@ibp.ac.cn